5/29/2025
Last update
5/29/2025
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
USERS' SCORE
Good
Based on 20 Reviews
8.6
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Inositol
500 mg
**
Top Medical Research Studies
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
Most Useful Reviews
9
Calms nerves effectively
77 people found this helpful
Inositol is beneficial for brain circuits and the nervous system. It effectively treats sleep disorders at dosages between 500 to 1500 mg daily. I noticed a significant reduction in nervousness after using it for a couple of weeks. It’s also helpful for calming children who may be restless or anxious.
Read More
9
Improved mental clarity
23 people found this helpful
Amazing product! I endured anxiety, panic attacks, and paranoia, which left me unable to make sound decisions. After being advised on the addictive nature of anxiety pills, I sought alternatives. I started researching and testing various herbs and vitamins individually. I even tried the placebo effect with my husband’s help. I can confidently say that Inositol repaired the injury my brain faced. I am now happier and more optimistic than I've been in decades. If you struggle with anxiety, I highly recommend giving this a try. It will be the best investment you've ever made, as everything aligns when your mind is clear, and you achieve peace and harmony.
Read More
9
Boosts neurotransmitters
14 people found this helpful
The most underrated supplement for ADHD, Inositol helps enhance serotonin and dopamine receptor density, improving the effectiveness of serotonin, GABA, glutamate, and dopamine neurotransmitters in my brain.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 2 Researches
7.5
- All Researches
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Read More
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Read More
User Reviews
USERS' SCORE
Good
Based on 20 Reviews
8.6
- All Reviews
- Positive Reviews
- Negative Reviews
9
Calms nerves effectively
77 people found this helpful
Inositol is beneficial for brain circuits and the nervous system. It effectively treats sleep disorders at dosages between 500 to 1500 mg daily. I noticed a significant reduction in nervousness after using it for a couple of weeks. It’s also helpful for calming children who may be restless or anxious.
Read More
9
Improved mental clarity
23 people found this helpful
Amazing product! I endured anxiety, panic attacks, and paranoia, which left me unable to make sound decisions. After being advised on the addictive nature of anxiety pills, I sought alternatives. I started researching and testing various herbs and vitamins individually. I even tried the placebo effect with my husband’s help. I can confidently say that Inositol repaired the injury my brain faced. I am now happier and more optimistic than I've been in decades. If you struggle with anxiety, I highly recommend giving this a try. It will be the best investment you've ever made, as everything aligns when your mind is clear, and you achieve peace and harmony.
Read More
9
Boosts neurotransmitters
14 people found this helpful
The most underrated supplement for ADHD, Inositol helps enhance serotonin and dopamine receptor density, improving the effectiveness of serotonin, GABA, glutamate, and dopamine neurotransmitters in my brain.
Read More
9
Regularised menstrual cycles
6 people found this helpful
Since taking Inositol, my periods have become regular, I've experienced no fatigue or brain fog after indulging in high-carb meals, and the symptoms of PCOS have vanished altogether. I enjoy a clearer complexion and fewer abdominal issues, making this supplement crucial for my health.
Read More
9
Essential for OCD
3 people found this helpful
Inositol is vital for my obsessive-compulsive disorder and has become indispensable for my children who are autistic. It’s crucial for maintaining brain and nerve health.
Read More
Frequently Asked Questions
9
Calms nerves effectively
77 people found this helpful
Inositol is beneficial for brain circuits and the nervous system. It effectively treats sleep disorders at dosages between 500 to 1500 mg daily. I noticed a significant reduction in nervousness after using it for a couple of weeks. It’s also helpful for calming children who may be restless or anxious.
1
Long-term use needed
Satisfactory, as it may enhance mood and reduce symptoms by influencing serotonin and dopamine receptors in the brain. However, one might need to consume it for an extended period, as no effect has been noticed after a week.
7.5
Mood stabilization
Since I began taking Inositol, I’ve noticed a marked improvement in my mood and reduction in anxiety on stressful days. The capsules are a convenient size, making it easy to continue the regimen. I have high hopes for this supplement, as it supports brain health and has gradually improved my concentration.
9
Improved mental clarity
23 people found this helpful
Amazing product! I endured anxiety, panic attacks, and paranoia, which left me unable to make sound decisions. After being advised on the addictive nature of anxiety pills, I sought alternatives. I started researching and testing various herbs and vitamins individually. I even tried the placebo effect with my husband’s help. I can confidently say that Inositol repaired the injury my brain faced. I am now happier and more optimistic than I've been in decades. If you struggle with anxiety, I highly recommend giving this a try. It will be the best investment you've ever made, as everything aligns when your mind is clear, and you achieve peace and harmony.
9
Regularised menstrual cycles
6 people found this helpful
Since taking Inositol, my periods have become regular, I've experienced no fatigue or brain fog after indulging in high-carb meals, and the symptoms of PCOS have vanished altogether. I enjoy a clearer complexion and fewer abdominal issues, making this supplement crucial for my health.
9
Comprehensive benefits
31 people found this helpful
I approached this review as a chance to highlight the dietary supplement inositol. Prescribed by a specialist, it has improved my brain and nervous system activity. It enhances memory and concentration while also being synthesised by the body, making it crucial for brain cells.
9
Improved egg quality
1 people found this helpful
Excellent! Inositol, taken in 500 mg doses twice daily, is important for brain function, carbohydrate metabolism, and calcium balance. It’s essential for cell membranes and notably improves egg quality, crucial when planning a pregnancy. I use it with Vitamins C, B, D, and Pregnenolone.
7.5
Stress relief
5 people found this helpful
Inositol has been calming for me. I learned about it through a supplement and opted to replace my theanine intake, which occasionally made me sleepy. Inositol does not induce drowsiness and helps quiet my racing thoughts. I believe combining it with other calming supplements could enhance its benefits, especially in our stressful society.
7.5
Strong effects noticed
I'm uncertain—this might be too strong. Dr Huberman recommends this with GABA, and the combined effects are quite powerful. My brain feels exceptionally alert and active, the opposite of sleepy, which is unusual. The dosage may be too high for me, or perhaps it's simply not suitable.
6
Effective for anxiety
1 people found this helpful
Taking Inositol to protect my liver led me to consider its impact on my brain. It seems effective for my anxiety levels; I feel more at ease in situations that typically cause me stress. Although I’m not sure if it’s simply my imagination, I'm keen to try a powdered version from another brand.
9
Aids hormonal balance
161 people found this helpful
Inositol, or vitamin B8, plays a crucial role in cellular structure and metabolism, especially in brain cells. I’ve found it helps improve hormonal balance, which is key for homeostasis. This supplement could be essential for those facing hormonal issues. Always consult a doctor before usage.
8
We explored the effects of inositol treatment on medulloblastoma, which is a leading cause of brain tumors in children. Specifically, we found that some medulloblastoma cells showed a unique sensitivity to changes in inositol metabolism due to the presence of the BMI1 gene.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
Our research focused on a particular sub-group of this tumor that is characterized by a specific gene signature known as BMI1;CHD7. We discovered that treatment with a compound derived from inositol, called IP6, could effectively counteract the aggressive behaviors of these tumors, particularly through blocking the activation of a key metabolic pathway called mTOR.
Additionally, our findings revealed that IP6 does not just work in isolation. When combined with cisplatin, a common chemotherapy drug, IP6 enhanced the drug's ability to kill tumor cells in laboratory settings. This combination also proved beneficial in a pre-clinical model, where it extended survival in mice with tumors that mirrored human medulloblastoma.
Overall, our study suggests that inositol and its derivatives could offer a novel avenue for treatment, particularly for tumors that carry the BMI1;CHD7 signature. However, we emphasize the need for further research to fully understand the potential benefits and mechanisms at play.
7
We examined how INPP5E influences Sonic Hedgehog (SHH) signaling in medulloblastoma, a common pediatric brain tumor. By using a murine model, we found that deleting INPP5E reduced tumor growth, cell proliferation, and SHH signaling while causing a loss of cilia on tumor cells.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
Our findings suggest that INPP5E is crucial for maintaining primary cilia and promoting tumor progression. Interestingly, we observed that lower levels of INPP5E in human samples correlated with better survival outcomes, highlighting its potential as a therapeutic target in combating SHH medulloblastoma.
References
- Badodi S, Pomella N, Zhang X, Rosser G, Whittingham J, et al. Inositol treatment inhibits medulloblastoma through suppression of epigenetic-driven metabolic adaptation. Nat Commun. 2021;12:2148. 10.1038/s41467-021-22379-7
- Conduit SE, Ramaswamy V, Remke M, Watkins DN, Wainwright BJ, et al. A compartmentalized phosphoinositide signaling axis at cilia is regulated by INPP5E to maintain cilia and promote Sonic Hedgehog medulloblastoma. Oncogene. 2017;36:5969. 10.1038/onc.2017.208
